KCNQ4

Across TCGA cell cohorts, KCNQ4 mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible KCNQ4-associated genes across cancer lineages are NKX2-6, GFRA4, and LINGO4. Each is linked with KCNQ4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNQ4-to-partner and partner-to-KCNQ4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKX2-6 grouped by KCNQ4-low versus KCNQ4-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ4→partner) and Y-score (partner→KCNQ4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NKX2-6 →	+0.491	+4.714	<.001	.002	3	2
BLOOD_Leukemia	GFRA4 →	+0.272	+4.824	.001	<.001	3	2
BLOOD_Leukemia	LINGO4 →	+0.201	+4.159	.001	.003	3	2
LARGE_INTESTINE	IAPP →	+0.278	+2.643	.002	.007	3	1
LARGE_INTESTINE	C9orf135 →	+0.072	+2.556	.007	.006	3	1
SKIN	CCNJ →	+0.430	+3.385	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

NKX2-6 by KCNQ4 expression — BLOOD_Lymphoma

Explore this box plot interactively →