KCNQ1-AS1

Across TCGA patient cohorts, KCNQ1-AS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,036 significant associations in total. STAD shows the largest number of these associations.

The most reproducible KCNQ1-AS1-associated GO terms across cancer lineages are Negative regulation of miRNA metabolic process, Kidney epithelium development, and Mesenchymal cell proliferation. Each is linked with KCNQ1-AS1 in more than 16 cancer types. Because this analysis shows association rather than direction, both KCNQ1-AS1-to-partner and partner-to-KCNQ1-AS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of miRNA metabolic process grouped by KCNQ1-AS1-low versus KCNQ1-AS1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ1-AS1→partner) and Y-score (partner→KCNQ1-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Negative regulation of miRNA metabolic process →	+0.062	+0.104	<.001	<.001	3	17
THYM	Kidney epithelium development →	+0.053	+0.186	<.001	<.001	3	17
TGCT	Mesenchymal cell proliferation →	+0.073	+0.139	<.001	<.001	3	17
TGCT	Negative regulation of cell growth →	+0.035	+0.126	<.001	<.001	3	17
TGCT	Regulation of mammary gland epithelial cell proliferation →	+0.063	+0.164	<.001	<.001	3	17
STAD	Regulation of actin filament organization →	+0.047	+0.123	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,036 associations by consensus.

Negative regulation of miRNA metabolic process by KCNQ1-AS1 expression — ESCA

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