KCNQ1-AS1

Across TCGA pan-cancer cohorts, KCNQ1-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated KCNQ1-AS1 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KCNQ1-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KCNQ1-AS1 expression acts as an unfavorable survival marker, although some lineages such as UVM and GBM show a favorable association.

UCEC, UVM, and STAD are the cancer types where KCNQ1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.537	0.727	<.001	100	view →
UVM	DFS	Median	All	0.728	0.465	.003	57	view →
STAD	OS	Median	All	0.277	0.523	.008	28	view →
LUSC	DFS	Median	II,III,IV	0.582	0.888	<.001	27	view →
GBM	DFS	Quartile	All	0.376	0.177	<.001	24	view →
THYM	DFS	Median	II,III,IV	0.944	0.751	.005	20	view →
LIHC	OS	Tertile	All	0.600	0.718	.008	18	view →
COAD	DFS	Median	All	0.712	0.841	.004	12	view →
KIRC	DFS	Median	All	0.556	0.682	.008	10	view →
SKCM	OS	Tertile	IV	0.415	0.861	.014	9	view →
MESO	DFS	Quartile	II,III,IV	0.248	0.532	.008	9	view →
PCPG	DFS	Median	All	0.507	0.890	.012	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

KCNQ1-AS1–UCEC (OS)

Open the UCEC breakdown →