KCNQ1-AS1

Across TCGA pan-cancer cohorts, KCNQ1-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of KCNQ1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where KCNQ1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types KCNQ1-AS1 is over-expressed in tumor, although a few such as KIRP and LUSC show the opposite, repressed pattern.

KIRP, LUSC, and BRCA are the cancer types where KCNQ1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNQ1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	All	−0.120	<.001	8	view →
LUSC	Male	II,III,IV	−0.236	<.001	7	view →
BRCA	All	II,III,IV	−0.165	<.001	6	view →
KIRC	All	II,III,IV	−0.061	.001	5	view →
COAD	Male	All	+0.058	.015	4	view →
LUAD	All	III,IV	−0.152	<.001	3	view →
UCEC	All	III,IV	−0.243	.013	2	view →
THCA	All	All	−0.093	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

KCNQ1-AS1–KIRP

Open the KIRP breakdown →