KCNK9

Across TCGA cell cohorts, KCNK9 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KCNK9-associated genes across cancer lineages are OR6B1, WFIKKN2, and KHDC3L. Each is linked with KCNK9 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNK9-to-partner and partner-to-KCNK9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6B1 grouped by KCNK9-low versus KCNK9-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK9→partner) and Y-score (partner→KCNK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR6B1 →	+0.020	+5.285	<.001	.003	3	1
BLOOD_Leukemia	WFIKKN2 →	+0.012	+3.954	<.001	.003	2	2
BLOOD_Leukemia	KHDC3L →	+0.170	+3.607	<.001	.004	3	1
BLOOD_Leukemia	DPRX →	+0.073	+3.890	<.001	<.001	3	1
LARGE_INTESTINE	TBC1D3 →	+0.076	+3.103	<.001	.004	3	1
BLOOD_Leukemia	AQP8 →	+0.106	+3.474	<.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OR6B1 by KCNK9 expression — STOMACH

Explore this box plot interactively →