KCNK16

Across TCGA patient cohorts, KCNK16 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNK16-associated genes across cancer lineages are JNK2, PDCD4, and EGFR_pY1068. Each is linked with KCNK16 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNK16-to-partner and partner-to-KCNK16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by KCNK16-low versus KCNK16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK16→partner) and Y-score (partner→KCNK16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.220	+2.817	.004	.001	3	2
UCEC	PDCD4 →	-0.595	-2.000	.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.234	-2.502	.017	.002	3	1
UCEC	ERK2 →	+0.158	+1.584	.036	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.211	-3.156	.001	<.001	3	1
UCEC	MEK1 →	+0.294	+2.115	.040	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

JNK2 by KCNK16 expression — UCEC

Explore this box plot interactively →