KCNK16

Across TCGA pan-cancer cohorts, KCNK16 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated KCNK16 data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher KCNK16 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KCNK16 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PAAD show a favorable association.

READ, DLBC, and KIRC are the cancer types where KCNK16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Tertile	All	0.620	0.858	<.001	72	view →
DLBC	DFS	Quartile	IV	0.146	0.704	.001	71	view →
KIRC	OS	Quartile	II,III,IV	0.393	0.616	.006	38	view →
ACC	OS	Tertile	All	0.133	0.686	.004	36	view →
LUAD	OS	Tertile	All	0.762	0.571	.001	36	view →
ESCA	OS	Tertile	All	0.442	0.948	<.001	28	view →
GBM	DFS	Tertile	All	0.176	0.275	.027	18	view →
LIHC	DFS	Tertile	III,IV	0.095	0.347	<.001	18	view →
THYM	OS	Tertile	III,IV	0.212	1.000	.045	12	view →
COAD	OS	Tertile	All	0.638	0.835	.005	12	view →
BLCA	OS	Tertile	IV	0.153	0.300	.028	9	view →
UVM	DFS	Tertile	III,IV	0.158	0.668	.035	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

KCNK16–READ (DFS)

Open the READ breakdown →