KCNK16

Across TCGA pan-cancer cohorts, KCNK16 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of KCNK16’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where KCNK16 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KCNK16 is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

UCEC, LUSC, and KIRC are the cancer types where KCNK16 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNK16 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	All	+0.058	.007	8	view →
LUSC	All	II,III,IV	−0.060	<.001	6	view →
KIRC	All	IV	+0.014	.004	6	view →
THCA	Male	All	−0.766	<.001	5	view →
COAD	All	All	+0.030	.009	3	view →
LIHC	Male	All	−0.018	.040	2	view →
KIRP	Male	All	−0.016	.026	2	view →
ESCA	All	All	−0.241	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

KCNK16–UCEC

Open the UCEC breakdown →