KCNK16

Across TCGA cell cohorts, KCNK16 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible KCNK16-associated genes across cancer lineages are OR2T33, NPHS2, and SERPINA7. Each is linked with KCNK16 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNK16-to-partner and partner-to-KCNK16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T33 grouped by KCNK16-low versus KCNK16-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK16→partner) and Y-score (partner→KCNK16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR2T33 →	+0.413	+3.869	.002	.002	3	2
LUNG_SCLC	NPHS2 →	+0.012	+3.232	<.001	.008	3	1
LUNG_SCLC	SERPINA7 →	+0.028	+3.232	.004	.008	3	1
LUNG_SCLC	KLRC1 →	+0.108	+3.750	.005	.003	3	1
LUNG_SCLC	CCDC197 →	+0.038	+3.684	.005	.001	3	1
LUNG_SCLC	AMY2A →	+0.905	+3.070	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OR2T33 by KCNK16 expression — LUNG_SCLC

Explore this box plot interactively →