KCNK1

Across TCGA patient cohorts, KCNK1 mutation is significantly associated with the RNA expression of many other genes, with 4,341 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNK1-associated genes across cancer lineages are ELP6, C16orf91, and MYPOP. Each is linked with KCNK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNK1-to-partner and partner-to-KCNK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELP6 grouped by KCNK1-low versus KCNK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK1→partner) and Y-score (partner→KCNK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ELP6 →	+0.374	+2.924	.001	.001	3	3
UCEC	C16orf91 →	+0.753	+3.269	<.001	<.001	3	3
UCEC	MYPOP →	+0.337	+2.606	.009	<.001	3	3
UCEC	DAZAP1 →	+0.360	+2.119	<.001	.003	3	3
UCEC	RPL23AP82 →	+0.617	+3.721	<.001	<.001	3	3
UCEC	CMC1 →	+0.409	+2.627	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,341 associations by consensus.

ELP6 by KCNK1 expression — UCEC

Explore this box plot interactively →