KCNK1

Across TCGA pan-cancer cohorts, KCNK1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KCNK1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KCNK1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KCNK1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, THCA, and KICH are the cancer types where KCNK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.920	<.001	11	view →
THCA	All	IV	+0.892	<.001	11	view →
KICH	All	II,III,IV	−1.839	<.001	8	view →
BLCA	Male	III,IV	+1.355	<.001	7	view →
BRCA	All	III,IV	+1.521	<.001	6	view →
UCEC	All	All	+1.228	<.001	6	view →
LUAD	Female	All	+1.212	<.001	6	view →
LUSC	Male	All	+1.201	<.001	4	view →
PAAD	All	All	+3.045	.005	2	view →
CHOL	Male	All	+1.891	.002	2	view →
STAD	Male	All	+1.346	.006	2	view →
ESCA	All	All	+0.924	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KCNK1–HNSC

Open the HNSC breakdown →