KCNK1

Across TCGA pan-cancer cohorts, KCNK1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated KCNK1 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher KCNK1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KCNK1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and LIHC show a favorable association.

UVM, KIRP, and SCLC are the cancer types where KCNK1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.417	0.763	<.001	104	view →
KIRP	OS	Quartile	All	0.614	0.859	<.001	95	view →
SCLC	DFS	Tertile	III,IV	0.195	0.647	.003	55	view →
LUSC	DFS	Tertile	II,III,IV	0.932	0.555	.001	48	view →
LAML	DFS	Tertile	All	0.203	0.597	.002	36	view →
PAAD	DFS	Quartile	All	0.235	0.577	.001	28	view →
LIHC	OS	Median	All	0.671	0.427	.003	25	view →
BRCA	OS	Tertile	II,III,IV	0.485	0.650	.004	25	view →
CESC	OS	Tertile	IV	0.692	0.088	.012	24	view →
UCEC	DFS	Quartile	III,IV	0.726	0.419	.011	24	view →
ESCA	OS	Median	IV	0.222	0.698	.006	24	view →
OV	OS	Median	IV	0.624	0.867	.007	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

KCNK1–UVM (DFS)

Open the UVM breakdown →