KCNK1

Across TCGA cell cohorts, KCNK1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNK1-associated genes across cancer lineages are PIWIL3, ADIG, and CNGA2. Each is linked with KCNK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNK1-to-partner and partner-to-KCNK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIWIL3 grouped by KCNK1-low versus KCNK1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK1→partner) and Y-score (partner→KCNK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PIWIL3 →	+0.025	+3.196	<.001	.007	3	1
BLOOD_Leukemia	ADIG →	+0.030	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	CNGA2 →	+0.099	+5.539	<.001	.003	3	1
BLOOD_Leukemia	GALP →	+0.068	+5.201	<.001	.006	3	1
BLOOD_Leukemia	MT1HL1 →	+0.237	+4.922	.006	.009	3	1
BLOOD_Leukemia	OR10G4 →	+0.021	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PIWIL3 by KCNK1 expression — SKIN

Explore this box plot interactively →