KCNJ3

Across TCGA cell cohorts, KCNJ3 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible KCNJ3-associated genes across cancer lineages are PRAMEF15, SPATA31A1, and GNGT1. Each is linked with KCNJ3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNJ3-to-partner and partner-to-KCNJ3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF15 grouped by KCNJ3-low versus KCNJ3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ3→partner) and Y-score (partner→KCNJ3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PRAMEF15 →	+0.345	+4.981	<.001	.008	3	2
PANCREAS	SPATA31A1 →	+0.005	+4.614	<.001	.004	3	1
BLOOD_Leukemia	GNGT1 →	+0.047	+3.551	.001	.009	3	1
BLOOD_Leukemia	FDCSP →	+0.156	+3.874	<.001	.005	3	1
BLOOD_Leukemia	IGFL1 →	+0.090	+3.769	<.001	.008	3	1
BLOOD_Leukemia	TLE7 →	+0.027	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

PRAMEF15 by KCNJ3 expression — CNS

Explore this box plot interactively →