KCNJ3

Across TCGA pan-cancer cohorts, KCNJ3 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated KCNJ3 data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher KCNJ3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated KCNJ3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KIRC, UVM, and BRCA are the cancer types where KCNJ3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.689	0.561	<.001	142	view →
UVM	DFS	Median	All	0.411	0.953	<.001	50	view →
BRCA	DFS	Tertile	III,IV	0.957	0.790	<.001	42	view →
LGG	DFS	Tertile	All	0.778	0.602	<.001	36	view →
ESCA	DFS	Tertile	II,III,IV	0.120	0.831	.005	32	view →
UCEC	DFS	Quartile	All	0.524	0.724	.001	32	view →
PAAD	DFS	Quartile	All	0.449	0.164	.004	31	view →
SCLC	OS	Median	All	0.442	0.960	.001	26	view →
COAD	DFS	Quartile	IV	0.245	0.664	.005	20	view →
THCA	DFS	Median	IV	0.489	1.000	.008	16	view →
LUSC	DFS	Quartile	III,IV	0.577	0.269	.023	15	view →
LUAD	DFS	Tertile	All	0.857	0.725	.014	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

KCNJ3–KIRC (DFS)

Open the KIRC breakdown →