KCNJ14

Across TCGA cell cohorts, KCNJ14 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNJ14-associated genes across cancer lineages are DNAAF6, GUCA1C, and KCTD8. Each is linked with KCNJ14 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNJ14-to-partner and partner-to-KCNJ14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAAF6 grouped by KCNJ14-low versus KCNJ14-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ14→partner) and Y-score (partner→KCNJ14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DNAAF6 →	+0.041	+3.693	<.001	.009	3	1
LARGE_INTESTINE	GUCA1C →	+0.123	+4.095	.008	.009	3	1
LARGE_INTESTINE	KCTD8 →	+0.188	+4.095	.002	.009	3	1
LARGE_INTESTINE	TBC1D3 →	+0.080	+4.273	<.001	.006	3	1
LARGE_INTESTINE	GSC2 →	+0.168	+4.273	<.001	.006	3	1
LARGE_INTESTINE	CHAT →	+0.035	+4.273	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

DNAAF6 by KCNJ14 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →