KCNJ14

Across TCGA pan-cancer cohorts, KCNJ14 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of KCNJ14’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where KCNJ14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KCNJ14 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

COAD, KIRC, and STAD are the cancer types where KCNJ14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNJ14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.157	<.001	12	view →
KIRC	Male	IV	+0.377	<.001	11	view →
STAD	All	All	+0.679	<.001	9	view →
THCA	All	All	−0.329	<.001	9	view →
KIRP	All	All	+0.292	.004	9	view →
LIHC	Male	II,III,IV	+0.540	<.001	8	view →
LUSC	Male	II,III,IV	+0.951	<.001	7	view →
UCEC	All	II,III,IV	+0.718	<.001	6	view →
BLCA	All	All	+0.478	.003	6	view →
HNSC	Male	All	+0.305	.002	5	view →
PAAD	Female	All	+0.705	.028	4	view →
LUAD	All	III,IV	+0.541	.009	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

KCNJ14–COAD

Open the COAD breakdown →