Across TCGA cell cohorts, KCNJ11 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KCNJ11-associated genes across cancer lineages are HES3, PPP1R2C, and CRISP1. Each is linked with KCNJ11 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNJ11-to-partner and partner-to-KCNJ11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ11→partner) and Y-score (partner→KCNJ11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HES3 →	+0.044	+5.321	<.001	.005	3	1
LARGE_INTESTINE	PPP1R2C →	+0.046	+4.095	<.001	.009	3	1
LARGE_INTESTINE	CRISP1 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1
LARGE_INTESTINE	KCNG4 →	+0.004	+4.415	<.001	.007	3	1
BLOOD_Leukemia	ADRA1A →	+0.232	+4.705	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

KCNJ11 survival (RNA) · tumor vs normal (RNA) · all KCNJ11 data types