KCNH4

Across TCGA patient cohorts, KCNH4 mutation is significantly associated with the RNA expression of many other genes, with 2,341 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNH4-associated genes across cancer lineages are MIR6802, TARS2P1, and MIR549A. Each is linked with KCNH4 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNH4-to-partner and partner-to-KCNH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6802 grouped by KCNH4-low versus KCNH4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH4→partner) and Y-score (partner→KCNH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR6802 →	+0.352	+4.203	<.001	<.001	3	3
PRAD	TARS2P1 →	+0.034	+5.288	<.001	.006	3	2
CESC	MIR549A →	+0.220	+4.342	<.001	.007	3	2
CESC	LDHAP1 →	+0.137	+3.754	<.001	.006	3	2
CESC	NF1P7 →	+0.022	+4.812	.003	<.001	3	2
BLCA	CBY1P1 →	+0.059	+3.082	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,341 associations by consensus.

MIR6802 by KCNH4 expression — BLCA

Explore this box plot interactively →