KCNH4

Across TCGA pan-cancer cohorts, KCNH4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KCNH4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KCNH4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KCNH4 is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where KCNH4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNH4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.179	<.001	10	view →
COAD	All	II,III,IV	+0.493	<.001	8	view →
LIHC	Female	II,III,IV	+0.259	<.001	8	view →
BRCA	All	II,III,IV	−0.213	<.001	6	view →
LUAD	All	All	+0.194	<.001	6	view →
STAD	All	II,III,IV	+0.393	.003	4	view →
UCEC	All	All	−0.227	.010	4	view →
HNSC	All	All	+0.117	.006	4	view →
KIRP	Female	All	+0.403	.043	2	view →
PRAD	All	All	−0.295	<.001	2	view →
CHOL	All	All	+0.745	.020	1	view →
KICH	Female	III,IV	−0.113	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KCNH4–KIRC

Open the KIRC breakdown →