KCNH1-IT1

Across TCGA pan-cancer cohorts, KCNH1-IT1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated KCNH1-IT1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher KCNH1-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KCNH1-IT1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and PAAD show a favorable association.

KIRC, BRCA, and MESO are the cancer types where KCNH1-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.490	0.672	<.001	198	view →
BRCA	OS	Tertile	All	0.983	0.944	<.001	121	view →
MESO	OS	Quartile	All	0.251	0.441	.007	78	view →
KIRP	DFS	Tertile	All	0.823	0.935	.001	67	view →
BLCA	DFS	Tertile	All	0.164	0.381	.001	60	view →
LIHC	DFS	Tertile	II,III,IV	0.107	0.484	<.001	54	view →
PAAD	DFS	Quartile	All	0.506	0.208	<.001	34	view →
LGG	OS	Tertile	All	0.599	0.411	<.001	34	view →
THCA	DFS	Median	III,IV	0.944	0.734	.007	30	view →
PCPG	DFS	Quartile	All	0.987	0.832	.005	28	view →
SKCM	OS	Quartile	All	0.241	0.468	<.001	25	view →
UVM	DFS	Tertile	All	0.412	0.653	.005	25	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

KCNH1-IT1–KIRC (OS)

Open the KIRC breakdown →