KCNH1-IT1

Across TCGA pan-cancer cohorts, KCNH1-IT1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of KCNH1-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where KCNH1-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KCNH1-IT1 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

BRCA, HNSC, and KIRC are the cancer types where KCNH1-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNH1-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	+0.801	<.001	8	view →
HNSC	All	II,III,IV	+0.314	.003	8	view →
KIRC	Male	II,III,IV	−0.291	<.001	8	view →
LUSC	All	All	+0.555	<.001	6	view →
COAD	Female	II,III,IV	−0.181	.001	6	view →
THCA	Male	All	+0.114	<.001	4	view →
KICH	All	All	−0.340	.016	2	view →
PRAD	All	All	−0.140	.001	2	view →
STAD	All	II,III,IV	−0.056	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

KCNH1-IT1–BRCA

Open the BRCA breakdown →