KCNE3

Across TCGA patient cohorts, KCNE3 mutation is significantly associated with the RNA expression of many other genes, with 125 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible KCNE3-associated genes across cancer lineages are FAM197Y4, TSPY12P, and FAM197Y6. Each is linked with KCNE3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNE3-to-partner and partner-to-KCNE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM197Y4 grouped by KCNE3-low versus KCNE3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNE3→partner) and Y-score (partner→KCNE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	FAM197Y4 →	+0.294	+5.742	<.001	.001	3	3
SKCM	TSPY12P →	+0.044	+4.411	<.001	.005	3	2
SKCM	FAM197Y6 →	+0.037	+4.411	<.001	.005	3	2
CESC	RNU6-644P →	+0.356	+4.193	.002	.009	3	2
LUSC	RNU6-1322P →	+0.329	+3.993	<.001	.005	3	2
LUSC	DNM1P32 →	+0.060	+4.297	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 125 associations by consensus.

FAM197Y4 by KCNE3 expression — LUSC

Explore this box plot interactively →