KCNE3

Across TCGA pan-cancer cohorts, KCNE3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of KCNE3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KCNE3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KCNE3 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KIRC, LIHC, and KICH are the cancer types where KCNE3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNE3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+2.304	<.001	12	view →
LIHC	Female	II,III,IV	+1.509	<.001	8	view →
KICH	Male	All	−1.066	<.001	7	view →
COAD	Female	II,III,IV	+1.374	<.001	6	view →
KIRP	Male	All	−0.605	.006	6	view →
BRCA	All	II,III,IV	−0.239	.022	6	view →
STAD	Male	All	+2.274	<.001	4	view →
CHOL	All	All	+1.792	.003	3	view →
LUSC	Male	All	−0.527	.033	3	view →
ESCA	All	II,III,IV	+4.545	.011	2	view →
PAAD	All	All	+1.295	.013	2	view →
LUAD	All	IV	−1.110	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

KCNE3–KIRC

Open the KIRC breakdown →