KCND3

Across TCGA patient cohorts, KCND3 mutation is significantly associated with the RNA expression of many other genes, with 3,537 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCND3-associated genes across cancer lineages are APOBEC3F, ADRA1B, and RN7SKP264. Each is linked with KCND3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCND3-to-partner and partner-to-KCND3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOBEC3F grouped by KCND3-low versus KCND3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCND3→partner) and Y-score (partner→KCND3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	APOBEC3F →	-0.890	-3.541	<.001	.002	3	3
LUAD	ADRA1B →	-0.806	-3.450	.003	.005	3	3
LUAD	RN7SKP264 →	+0.083	+2.698	.004	.005	3	3
SKCM	TTLL6 →	-0.429	-1.491	.004	.005	3	3
UCEC	PRIMA1 →	-0.834	-2.237	<.001	.001	3	3
UCEC	EMID1 →	-0.847	-1.262	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,537 associations by consensus.

APOBEC3F by KCND3 expression — LUAD

Explore this box plot interactively →