Across TCGA cell cohorts, KAZN mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KAZN-associated genes across cancer lineages are TBATA, OR10A3, and OR8D1. Each is linked with KAZN in more than 1 cancer types. Because this analysis shows association rather than direction, both KAZN-to-partner and partner-to-KAZN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAZN→partner) and Y-score (partner→KAZN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TBATA →	+0.154	+3.700	<.001	.005	3	2
LUNG_NSCLC_LUAD	OR10A3 →	+0.143	+3.906	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR8D1 →	+0.043	+3.343	.002	.005	3	1
LUNG_NSCLC_LUAD	IL27 →	+0.433	+3.695	<.001	.005	3	1
LUNG_NSCLC_LUAD	CROCC2 →	+0.208	+3.787	<.001	.004	3	1
LUNG_NSCLC_LUAD	PADI6 →	+0.044	+4.188	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

KAZN survival (RNA) · tumor vs normal (RNA) · all KAZN data types