KAT8

Across TCGA cell cohorts, KAT8 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KAT8-associated genes across cancer lineages are NXPE4, LCE2A, and SHISA6. Each is linked with KAT8 in more than 1 cancer types. Because this analysis shows association rather than direction, both KAT8-to-partner and partner-to-KAT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NXPE4 grouped by KAT8-low versus KAT8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT8→partner) and Y-score (partner→KAT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NXPE4 →	+0.027	+4.276	<.001	.007	3	1
BLOOD_Leukemia	LCE2A →	+0.069	+4.969	<.001	.003	3	1
BLOOD_Leukemia	SHISA6 →	+0.029	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	LYZL6 →	+0.029	+4.969	<.001	.003	3	1
LARGE_INTESTINE	PROP1 →	+0.036	+4.054	<.001	.004	3	1
LARGE_INTESTINE	TBC1D3 →	+0.083	+4.688	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

NXPE4 by KAT8 expression — BLOOD_Leukemia

Explore this box plot interactively →