KAT6B

Across TCGA cell cohorts, KAT6B mutation is significantly associated with the RNA expression of many other genes, with 1,126 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KAT6B-associated genes across cancer lineages are CEP85, GJA8, and TUBB8. Each is linked with KAT6B in more than 2 cancer types. Because this analysis shows association rather than direction, both KAT6B-to-partner and partner-to-KAT6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEP85 grouped by KAT6B-low versus KAT6B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT6B→partner) and Y-score (partner→KAT6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CEP85 →	+0.544	+2.386	.009	.007	3	3
BLOOD_Lymphoma	GJA8 →	+0.017	+2.807	.002	.004	3	2
BLOOD_Lymphoma	TUBB8 →	+0.176	+3.614	.002	.002	3	2
OVARY	FNDC9 →	+0.020	+3.402	.005	.007	3	2
LARGE_INTESTINE	ANKRD54 →	+0.473	+2.389	<.001	.006	3	2
LUNG_NSCLC_LUAD	SNU13 →	+0.440	+2.495	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,126 associations by consensus.

CEP85 by KAT6B expression — LARGE_INTESTINE

Explore this box plot interactively →