KAT6B

Across TCGA pan-cancer cohorts, KAT6B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of KAT6B’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where KAT6B RNA is repressed in tumor relative to normal tissue. In most cancer types KAT6B is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, BRCA, and COAD are the cancer types where KAT6B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KAT6B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−0.945	<.001	8	view →
BRCA	All	II,III,IV	+0.389	<.001	6	view →
COAD	All	All	−0.352	<.001	5	view →
LUAD	Female	All	−0.528	<.001	4	view →
LIHC	All	All	+0.308	.001	4	view →
CHOL	Male	All	+1.470	<.001	3	view →
STAD	Female	All	−0.732	.005	2	view →
LUSC	Female	II,III,IV	−0.612	.023	2	view →
UCEC	All	All	−0.603	.004	2	view →
KIRP	Male	All	−0.478	.002	2	view →
THCA	All	All	−0.290	.029	2	view →
READ	All	All	−0.611	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

KAT6B–BLCA

Open the BLCA breakdown →