KAT5

Across TCGA cell cohorts, KAT5 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KAT5-associated genes across cancer lineages are GML, ADAD1, and OR6C70. Each is linked with KAT5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KAT5-to-partner and partner-to-KAT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GML grouped by KAT5-low versus KAT5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAT5→partner) and Y-score (partner→KAT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.078	+4.152	<.001	.009	3	2
PANCREAS	ADAD1 →	+0.026	+5.614	<.001	.002	3	1
PANCREAS	OR6C70 →	+0.035	+5.000	<.001	.006	3	1
PANCREAS	DPPA3 →	+0.013	+5.614	<.001	.002	3	1
BLOOD_Leukemia	TCF21 →	+0.019	+4.705	<.001	.003	3	1
BLOOD_Leukemia	NXPE4 →	+0.020	+4.276	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

GML by KAT5 expression — BLOOD_Leukemia

Explore this box plot interactively →