KAT5

Across TCGA pan-cancer cohorts, KAT5 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of KAT5’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where KAT5 RNA is repressed in tumor relative to normal tissue. In most cancer types KAT5 is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

LUAD, THCA, and LIHC are the cancer types where KAT5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KAT5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−0.587	<.001	9	view →
THCA	All	All	−0.378	<.001	9	view →
LIHC	Female	II,III,IV	+0.895	<.001	8	view →
UCEC	All	All	−1.005	<.001	6	view →
KICH	All	All	−0.437	<.001	6	view →
COAD	Female	All	+0.375	.001	5	view →
CHOL	Female	All	+1.606	<.001	3	view →
KIRP	Male	All	−0.489	<.001	3	view →
READ	All	All	−0.523	.002	2	view →
HNSC	All	All	+0.250	.027	2	view →
LUSC	All	All	−0.213	.005	2	view →
PRAD	All	All	−0.203	.043	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

KAT5–LUAD

Open the LUAD breakdown →