KASH5

Across TCGA cell cohorts, KASH5 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KASH5-associated genes across cancer lineages are OR9G1, HMHB1, and IL17A. Each is linked with KASH5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KASH5-to-partner and partner-to-KASH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9G1 grouped by KASH5-low versus KASH5-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KASH5→partner) and Y-score (partner→KASH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR9G1 →	+0.030	+5.087	<.001	.004	3	1
SKIN	HMHB1 →	+0.076	+6.022	<.001	.001	3	1
STOMACH	IL17A →	+0.040	+5.285	<.001	.003	3	1
STOMACH	OR8D4 →	+0.043	+5.285	<.001	.003	3	1
LUNG_NSCLC_LUAD	XAGE3 →	+0.128	+4.215	<.001	.002	3	1
LUNG_NSCLC_LUAD	KHDC3L →	+0.032	+4.215	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR9G1 by KASH5 expression — URINARY_TRACT

Explore this box plot interactively →