JOSD2

Across TCGA patient cohorts, JOSD2 mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JOSD2-associated genes across cancer lineages are RNU6-445P, DUX4L4, and TTTY6. Each is linked with JOSD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both JOSD2-to-partner and partner-to-JOSD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-445P grouped by JOSD2-low versus JOSD2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JOSD2→partner) and Y-score (partner→JOSD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-445P →	+0.522	+7.930	<.001	.008	3	2
LUAD	DUX4L4 →	+0.019	+7.930	<.001	.008	3	2
LUAD	TTTY6 →	+0.044	+7.930	<.001	.008	3	1
LUAD	KRTAP9-8 →	+0.044	+7.930	<.001	.008	3	1
LUAD	MT-TQ →	+0.417	+7.930	<.001	.008	3	1
LUAD	RN7SKP222 →	+0.069	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

RNU6-445P by JOSD2 expression — LUAD

Explore this box plot interactively →