JOSD2

Across TCGA cell cohorts, JOSD2 mutation is significantly associated with the mutation status of many other genes, with 2,195 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible JOSD2-associated genes across cancer lineages are MPP4, CHGA, and FAM83D. Each is linked with JOSD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both JOSD2-to-partner and partner-to-JOSD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPP4 grouped by JOSD2-low versus JOSD2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JOSD2→partner) and Y-score (partner→JOSD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MPP4 →	+3.459	+4.000	<.001	<.001	1	2
LARGE_INTESTINE	CHGA →	+4.044	+3.744	.003	.003	1	2
LARGE_INTESTINE	FAM83D →	+3.459	+3.459	.006	.006	1	2
LARGE_INTESTINE	SYP →	+5.044	+4.087	.001	.001	1	2
LARGE_INTESTINE	ARHGEF7 →	+2.459	+3.321	.005	.005	1	2
LARGE_INTESTINE	GDPD3 →	+4.044	+3.744	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,195 associations by consensus.

MPP4 by JOSD2 expression — LARGE_INTESTINE

Explore this box plot interactively →