JMJD7-PLA2G4B

Across TCGA cell cohorts, JMJD7-PLA2G4B mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible JMJD7-PLA2G4B-associated genes across cancer lineages are DEFA4, TBC1D21, and WDR87. Each is linked with JMJD7-PLA2G4B in more than 1 cancer types. Because this analysis shows association rather than direction, both JMJD7-PLA2G4B-to-partner and partner-to-JMJD7-PLA2G4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by JMJD7-PLA2G4B-low versus JMJD7-PLA2G4B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JMJD7-PLA2G4B→partner) and Y-score (partner→JMJD7-PLA2G4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	WDR87 →	+0.021	+3.453	<.001	.009	3	1
LARGE_INTESTINE	ACSM6 →	+0.023	+3.658	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	MPC1L →	+0.045	+4.510	<.001	.003	3	1
BLOOD_Leukemia	TSSK1B →	+0.011	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

DEFA4 by JMJD7-PLA2G4B expression — LARGE_INTESTINE

Explore this box plot interactively →