JMJD7-PLA2G4B

Across TCGA pan-cancer cohorts, JMJD7-PLA2G4B RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated JMJD7-PLA2G4B data layer compared with 9 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher JMJD7-PLA2G4B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated JMJD7-PLA2G4B expression acts as an unfavorable survival marker, although some lineages such as SCLC and HNSC show a favorable association.

KIRC, SCLC, and HNSC are the cancer types where JMJD7-PLA2G4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.515	0.733	.004	75	view →
SCLC	DFS	Median	All	0.575	0.256	<.001	71	view →
HNSC	DFS	Median	IV	0.710	0.569	.004	64	view →
COAD	DFS	Quartile	All	0.225	0.755	<.001	59	view →
UVM	DFS	Tertile	III,IV	0.202	0.855	<.001	44	view →
UCEC	OS	Median	III,IV	0.723	0.443	.001	36	view →
PRAD	DFS	Median	All	0.836	0.926	.001	28	view →
SKCM	OS	Median	IV	1.000	0.257	.001	24	view →
STAD	DFS	Quartile	II,III,IV	0.435	0.678	.005	23	view →
BRCA	OS	Median	III,IV	0.951	0.854	.010	16	view →
ACC	DFS	Quartile	All	0.238	0.731	.006	13	view →
ESCA	OS	Quartile	All	0.810	0.605	.043	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

JMJD7-PLA2G4B–KIRC (DFS)

Open the KIRC breakdown →