JAG1

Across TCGA cell cohorts, JAG1 mutation is significantly associated with the RNA expression of many other genes, with 1,019 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible JAG1-associated genes across cancer lineages are GSG1L2, ACTRT1, and KLHL40. Each is linked with JAG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both JAG1-to-partner and partner-to-JAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by JAG1-low versus JAG1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAG1→partner) and Y-score (partner→JAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSG1L2 →	+0.028	+3.969	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	ACTRT1 →	+0.066	+4.870	<.001	.001	3	2
UPPER_AERODIGESTIVE_TRACT	KLHL40 →	+0.019	+4.870	<.001	.001	3	2
UPPER_AERODIGESTIVE_TRACT	GPR148 →	+0.047	+4.357	<.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	CNGA2 →	+0.050	+4.357	<.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	ARGFX →	+0.062	+4.357	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,019 associations by consensus.

GSG1L2 by JAG1 expression — BLOOD_Leukemia

Explore this box plot interactively →