ITIH5

Across TCGA cell cohorts, ITIH5 mutation is significantly associated with the RNA expression of many other genes, with 572 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITIH5-associated genes across cancer lineages are OR13C4, SH3GL2, and FAM149A. Each is linked with ITIH5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITIH5-to-partner and partner-to-ITIH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13C4 grouped by ITIH5-low versus ITIH5-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH5→partner) and Y-score (partner→ITIH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	OR13C4 →	+0.023	+5.000	<.001	.005	3	2
BLOOD_Leukemia	SH3GL2 →	+0.360	+3.215	.004	.005	3	2
BLOOD_Leukemia	FAM149A →	+0.709	+3.727	.006	<.001	3	2
BLOOD_Leukemia	SGCB →	+1.469	+3.489	<.001	.001	3	2
BLOOD_Leukemia	HASPIN →	+0.786	+3.215	.002	.005	3	2
BLOOD_Leukemia	FAM221A →	+1.972	+3.489	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 572 associations by consensus.

OR13C4 by ITIH5 expression — KIDNEY

Explore this box plot interactively →