ITIH5

Across TCGA pan-cancer cohorts, ITIH5 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ITIH5’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ITIH5 RNA is repressed in tumor relative to normal tissue. In most cancer types ITIH5 is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

BLCA, LUAD, and COAD are the cancer types where ITIH5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITIH5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−4.180	<.001	11	view →
LUAD	Female	III,IV	−2.512	<.001	11	view →
COAD	Male	II,III,IV	−1.398	<.001	11	view →
KIRP	Female	II,III,IV	−3.301	<.001	9	view →
LUSC	Female	II,III,IV	−3.002	<.001	8	view →
BRCA	All	III,IV	−3.618	<.001	6	view →
UCEC	All	All	−2.374	<.001	6	view →
THCA	All	All	−0.563	.001	5	view →
KICH	All	All	−1.170	.003	4	view →
CHOL	Female	All	+6.313	<.001	3	view →
READ	All	All	−2.161	<.001	3	view →
STAD	All	All	−0.967	.016	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ITIH5–BLCA

Open the BLCA breakdown →