ITIH1

Across TCGA cell cohorts, ITIH1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ITIH1-associated genes across cancer lineages are KHDC3L, RBP3, and KRTAP22-2. Each is linked with ITIH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITIH1-to-partner and partner-to-ITIH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KHDC3L grouped by ITIH1-low versus ITIH1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITIH1→partner) and Y-score (partner→ITIH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KHDC3L →	+0.202	+3.096	<.001	.005	3	2
BLOOD_Leukemia	RBP3 →	+0.020	+3.661	<.001	.001	3	2
BONE	KRTAP22-2 →	+0.290	+5.169	<.001	.004	3	1
STOMACH	SSTR4 →	+0.059	+4.129	<.001	.007	3	1
BLOOD_Leukemia	ADAMTS18 →	+0.636	+3.605	<.001	.007	3	1
BLOOD_Leukemia	OR1J4 →	+0.113	+2.948	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

KHDC3L by ITIH1 expression — BLOOD_Leukemia

Explore this box plot interactively →