ITGB3BP

Across TCGA patient cohorts, ITGB3BP mutation is significantly associated with the RNA expression of many other genes, with 344 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGB3BP-associated genes across cancer lineages are RNA5SP407, RNA5SP408, and RNA5SP410. Each is linked with ITGB3BP in more than 1 cancer types. Because this analysis shows association rather than direction, both ITGB3BP-to-partner and partner-to-ITGB3BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP407 grouped by ITGB3BP-low versus ITGB3BP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB3BP→partner) and Y-score (partner→ITGB3BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP407 →	+0.374	+3.437	<.001	.004	3	2
UCEC	RNA5SP408 →	+0.370	+3.379	.001	.001	3	2
UCEC	RNA5SP410 →	+0.870	+2.526	<.001	.007	3	2
BRCA	MIR7159 →	+0.954	+5.317	<.001	.006	3	1
UCEC	NOL12 →	+0.426	+3.354	.005	.005	3	1
UCEC	MIR6832 →	+0.877	+3.180	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 344 associations by consensus.

RNA5SP407 by ITGB3BP expression — UCEC

Explore this box plot interactively →