ITGB3BP

Across TCGA pan-cancer cohorts, ITGB3BP RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ITGB3BP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ITGB3BP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ITGB3BP is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, HNSC, and LIHC are the cancer types where ITGB3BP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITGB3BP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	+0.440	<.001	12	view →
HNSC	Male	IV	+0.768	<.001	11	view →
LIHC	Male	II,III,IV	+1.323	<.001	9	view →
LUAD	Male	All	+0.673	<.001	9	view →
STAD	All	II,III,IV	+0.709	<.001	7	view →
COAD	Male	All	+0.625	<.001	7	view →
BLCA	Female	All	+1.002	<.001	6	view →
BRCA	All	II,III,IV	+0.357	<.001	6	view →
CHOL	Male	All	+2.150	<.001	5	view →
KICH	Female	All	−1.397	<.001	5	view →
LUSC	All	All	+0.495	<.001	5	view →
READ	All	II,III,IV	+0.827	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ITGB3BP–KIRC

Open the KIRC breakdown →