ITGB3BP

Across TCGA pan-cancer cohorts, ITGB3BP RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ITGB3BP data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher ITGB3BP RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITGB3BP expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

KICH, LIHC, and ACC are the cancer types where ITGB3BP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Quartile	II,III,IV	0.273	0.916	<.001	93	view →
LIHC	DFS	Median	All	0.439	0.643	<.001	71	view →
ACC	OS	Median	All	0.772	0.969	<.001	58	view →
LGG	DFS	Median	All	0.639	0.832	<.001	54	view →
SARC	DFS	Tertile	All	0.376	0.616	<.001	36	view →
KIRC	DFS	Tertile	IV	0.354	0.677	.011	27	view →
UCEC	OS	Tertile	II,III,IV	0.774	0.504	.009	24	view →
MESO	DFS	Tertile	IV	0.207	0.617	.011	19	view →
LUAD	DFS	Tertile	IV	0.715	0.160	.013	18	view →
THCA	DFS	Median	IV	0.462	0.840	.008	18	view →
READ	OS	Median	II,III,IV	1.000	0.849	.008	14	view →
SCLC	DFS	Quartile	All	0.463	0.685	.020	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ITGB3BP–KICH (DFS)

Open the KICH breakdown →