ITGB3BP

Across TCGA patient cohorts, ITGB3BP mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGB3BP-associated genes across cancer lineages are 14-3-3_beta, Tuberin_pT1462, and Tuberin. Each is linked with ITGB3BP in more than 1 cancer types. Because this analysis shows association rather than direction, both ITGB3BP-to-partner and partner-to-ITGB3BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ITGB3BP-low versus ITGB3BP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB3BP→partner) and Y-score (partner→ITGB3BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.139	-3.156	.011	.020	3	1
UCEC	Tuberin_pT1462 →	+0.434	+3.009	<.001	.019	3	1
UCEC	Tuberin →	+0.394	+3.009	.007	.019	3	1
UCEC	ASNS →	+0.675	+3.169	<.001	.020	3	1
UCEC	TFRC →	+0.664	+3.169	.022	.020	2	1
UCEC	Caspase-8 →	-0.292	-3.169	.034	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

14-3-3_beta by ITGB3BP expression — UCEC

Explore this box plot interactively →