ITGB3BP

Across TCGA cell cohorts, ITGB3BP RNA expression is significantly associated with the go_rna of many other GO terms, with 4,242 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ITGB3BP-associated GO terms across cancer lineages are Regulation of chromosome separation, Regulation of mitotic sister chromatid segregation, and Regulation of mitotic nuclear division. Each is linked with ITGB3BP in more than 17 cancer types. Because this analysis shows association rather than direction, both ITGB3BP-to-partner and partner-to-ITGB3BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromosome separation grouped by ITGB3BP-low versus ITGB3BP-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGB3BP→partner) and Y-score (partner→ITGB3BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome separation →	+0.147	+0.957	.002	.007	3	18
BLOOD_Myeloma	Regulation of mitotic sister chromatid segregation →	+0.146	+1.401	<.001	<.001	3	18
SOFT_TISSUE	Regulation of mitotic nuclear division →	+0.120	+0.970	<.001	<.001	3	18
BLOOD_Myeloma	Positive regulation of chromosome condensation →	+0.252	+1.335	<.001	<.001	3	17
BLOOD_Myeloma	Negative regulation of mitotic sister chromatid separation →	+0.159	+1.398	.002	<.001	3	17
BLOOD_Myeloma	Negative regulation of sister chromatid segregation →	+0.159	+1.398	.002	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,242 associations by consensus.

Regulation of chromosome separation by ITGB3BP expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →