ITGAE

Across TCGA patient cohorts, ITGAE mutation is significantly associated with the RNA expression of many other genes, with 6,162 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGAE-associated genes across cancer lineages are RTN4IP1, ZMYND19, and C22orf46. Each is linked with ITGAE in more than 3 cancer types. Because this analysis shows association rather than direction, both ITGAE-to-partner and partner-to-ITGAE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTN4IP1 grouped by ITGAE-low versus ITGAE-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGAE→partner) and Y-score (partner→ITGAE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RTN4IP1 →	+0.393	+3.217	.009	.009	3	4
UCEC	ZMYND19 →	+0.395	+1.669	<.001	.001	3	4
SKCM	C22orf46 →	+0.349	+2.273	.003	.004	3	3
SKCM	PTP4A3 →	-0.967	-1.830	<.001	.001	3	3
SKCM	TMEM30A-DT →	+0.322	+2.409	<.001	.002	3	3
UCEC	TRAIP →	+0.401	+2.807	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,162 associations by consensus.

RTN4IP1 by ITGAE expression — LUAD

Explore this box plot interactively →