ITGAE

Across TCGA pan-cancer cohorts, ITGAE RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ITGAE data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ITGAE RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITGAE expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

KIRC, ACC, and KICH are the cancer types where ITGAE RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.520	0.729	<.001	127	view →
ACC	DFS	Median	All	0.232	0.672	<.001	116	view →
KICH	DFS	Median	All	0.674	0.977	<.001	95	view →
LGG	DFS	Median	All	0.656	0.814	<.001	49	view →
BLCA	DFS	Quartile	II,III,IV	0.609	0.425	.002	46	view →
UCEC	DFS	Median	III,IV	0.860	0.724	.004	42	view →
CESC	DFS	Tertile	All	0.704	0.427	<.001	38	view →
UVM	DFS	Tertile	III,IV	0.252	0.925	<.001	37	view →
LUSC	DFS	Quartile	II,III,IV	0.271	0.800	.001	22	view →
READ	DFS	Quartile	All	0.944	0.500	.007	18	view →
SCLC	DFS	Median	All	0.735	0.508	.008	16	view →
SKCM	DFS	Median	All	0.250	0.159	.001	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ITGAE–KIRC (DFS)

Open the KIRC breakdown →