ITGA7

Across TCGA patient cohorts, ITGA7 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGA7-associated genes across cancer lineages are ASNS, Smad4, and eIF4E. Each is linked with ITGA7 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITGA7-to-partner and partner-to-ITGA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ITGA7-low versus ITGA7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA7→partner) and Y-score (partner→ITGA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.587	+2.467	<.001	.011	3	3
COAD	Smad4 →	+0.151	+3.593	.008	.001	3	3
UCEC	eIF4E →	+0.203	+2.857	.001	<.001	3	2
UCEC	ACC_pS79 →	+0.309	+1.415	.004	.010	3	2
UCEC	ACC1 →	+0.456	+3.013	<.001	<.001	3	2
UCEC	Notch1 →	+0.160	+1.512	<.001	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

ASNS by ITGA7 expression — COAD

Explore this box plot interactively →