ITGA7

Across TCGA cell cohorts, ITGA7 mutation is significantly associated with the RNA expression of many other genes, with 241 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITGA7-associated genes across cancer lineages are ERCC8, DEFA4, and MAPK8. Each is linked with ITGA7 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITGA7-to-partner and partner-to-ITGA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERCC8 grouped by ITGA7-low versus ITGA7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA7→partner) and Y-score (partner→ITGA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ERCC8 →	+0.405	+3.169	.009	.009	3	3
LUNG_NSCLC_LUAD	DEFA4 →	+0.024	+4.662	<.001	.005	3	2
LARGE_INTESTINE	MAPK8 →	+0.630	+2.800	.003	.001	3	2
LARGE_INTESTINE	NPM3 →	+0.557	+2.628	.009	.002	3	2
LARGE_INTESTINE	NDUFC1 →	+0.673	+2.628	<.001	.002	3	2
LARGE_INTESTINE	PAICS →	+0.640	+2.714	.001	.002	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 241 associations by consensus.

ERCC8 by ITGA7 expression — LARGE_INTESTINE

Explore this box plot interactively →