ITGA10

Across TCGA patient cohorts, ITGA10 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGA10-associated genes across cancer lineages are mTOR_pS2448, PCNA, and Caspase-7-cleavedD198. Each is linked with ITGA10 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITGA10-to-partner and partner-to-ITGA10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ITGA10-low versus ITGA10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA10→partner) and Y-score (partner→ITGA10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.104	-2.308	.049	.033	3	3
UCEC	PCNA →	+0.260	+3.700	<.001	.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.679	+2.242	.001	.005	3	3
COAD	eEF2 →	+0.240	+1.593	.039	.043	3	3
COAD	EGFR_pY1068 →	-0.372	-3.321	.003	.009	3	2
UCEC	JNK2 →	+0.269	+2.000	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

mTOR_pS2448 by ITGA10 expression — UCEC

Explore this box plot interactively →